C-Myb Regulates Stem-Progenitor Cell Cycle Entry in Colonic Crypts Providing Insights Into Colo-Rectal Carcinogenesis
Grant number: 400216
Abstract
During a human's life time the colon or large bowel produced an extraordinary volume of cells. This requires almost unimaginable numbers of cell divisions. We are investigating the role of a gene (c-myb) that we propose is one of the key regulators of normal colon growth and function. It is expressed in the base of the functional unit of the colon called the colonic crypt. The base contains the stem cell population which give rise to all the crypt cells. We have generated and gathered a unique and comprehensive set of mutant mice that have various degrees of dysfunction of the c-myb gene. We will study the colons of these mice to determine how c-myb regulates cell growth. We will also invest..
View full description